摘要
Dear Editor,T-cell infection by SARS-CoV-2 and associated immune responses are correlated with disease severity and prognosis of COVID-19.Lymphopenia is associated with increased disease severity in COVID-19.Significantly lower circulating T and B cell counts were observed in patients who died from COVID-19 compared with survivors.Moreover,SARS-CoV-2 infection causes aberrant lymphocyte activation and dysfunction.
基金
This research was supported by the National Key R&D Program of China(2020YFA0509000 to J.C.)
the National Natural Science Foundation of China(32030024,31830112,and 31525016 to J.C.,92169112 and 82161138002 to S.J.)
Program of Shanghai Academic Research Leader(19XD1404200)
Shanghai Municipal Science and Technology Major Project(ZD2021CY001 to S.J)
National Ten Thousand Talents Program.The authors gratefully acknowledge the support of the SA-SIBS scholarship program.
