中国成年人群多肥胖指标与高尿酸血症之间的关系

Association between obesity indicators and hyperuricemia in Chinese adults

目的 寻找适用于预测中国成年人群中高尿酸血症(hyperuricemia, HUA)患者的肥胖指标。方法 计算2009年中国健康与营养调查的8 133例调查对象的各项肥胖指标,对其基本情况进行描述性分析。采用χ^(2)检验、t检验分别检验分类变量、连续型变量在HUA组和非HUA组之间的差异。绘制各肥胖指标的受试者工作特征(receiver operating characteristic, ROC)曲线,判断各肥胖指标预测HUA的准确性。采用二元logistic回归分析肥胖指标与HUA之间的关系。结果 人口学协变量、患病情况以及身体质量指数(body mass index, BMI)均会对HUA的患病产生影响。各肥胖指标对HUA均有良好的预测性,其中,脂质蓄积指数(lipid accumulation product, LAP)效果最佳,AUC=0.77(95%CI:0.75~0.78)。各肥胖指标均与HUA显著相关。未调整协变量时,LAP的OR值最高,OR=5.87 (95%CI:5.08~6.77)。结论 LAP指数与HUA显著相关,可作为评估中国成年肥胖人群HUA患病的新兴指标。

Objective The study aims to find a suitable obesity index for predicting hyperuricemia(HUA)in Chinese adults.Methods The obesity indexes of 8133 subjects in China Health and Nutrition Survey in 2009 were calculated,and the basic situation of them was analyzed descriptively.Χ^(2) test and t test were used to test the differences of categorical variables and continuous variables between the HUA group and the non-HUA group.The area under the curve(AUC)and receiver operating characteristic(ROC)curves were used to analyze the predictive value of these indices for HUA.Binary logistic regression was used to analyze the relationship between obesity and HUA.Results Demographic covariates,prevalence and Body Mass Index(BMI)all have impacts on the prevalence of HUA.Obesity indexes have a good predictive effect on HUA,and the Lipid Accumulation Product(LAP)is the best(AUC=0.77(95%CI[0.75,0.78]).Obesity indexes all have a significant correlation with HUA.When covariates were not adjusted,LAP had the highest OR value(OR=5.87,95%CI[5.08,6.77]).Conclusion LAP index is significantly related to HUA,and it can be used as an emerging index to assess the prevalence of HUA in Chinese adults.