苏州市8~10岁学龄儿童甲状腺结节患病率及影响因素分析

Prevalence and influencing factors of thyroid nodules in children aged 8-10 years old in Suzhou

目的探究苏州市8~10岁学龄儿童甲状腺结节患病率及其影响因素。方法采用PPS抽样法,对纳入对象进行问卷调查,体格检查及甲状腺B超检查,同时检测盐碘、尿碘含量。采用单因素及多因素logistic回归模型分析甲状腺结节患病相关的危险因素。结果共纳入调查对象2048人,其中甲状腺结节患病率23.34%(478/2048),男童结节患病率20.98%(218/1039),女童结节患病率25.77%(260/1009)。多因素分析显示,性别(OR=1.338,P=0.006)、身高(OR=1.993,P=0.001)、富碘食物摄入频率(OR=0.862,P=0.048)及是否补充营养制剂(OR=1.469,P=0.008)与甲状腺结节患病呈相关关系。结论苏州市8~10岁学龄儿童甲状腺结节患病率23.34%,女性、身高偏高、富碘食物经常摄入及补充营养制剂与甲状腺结节患病存在统计学关联,有可能是患病的危险因素,但尚需进一步研究证实。

Objective To investigate the prevalence and influencing factors of thyroid nodules in children aged 8-10 years in Suzhou,and to provide a scientific basis for the rational prevention and treatment of iodine deficiency disorders(IDD).Methods PPS sampling method was used in this study.Questionnaire survey,physical examination and thyroid Bultrasound examination were conducted on students aged 8-10 years.Salt samples and urine samples were collected for laboratory detection of the salt iodine and urinary iodine.Univariate and multivariate logistic regression models were used to analyze the risk factors related to thyroid nodules.Results A total of 2048 children aged 8-10 years were included in the present survey,and the prevalence of thyroid nodules was 23.34%(478/2048).The prevalence of nodules in boys was 20.98%(218/1039),and the prevalence of nodules in girls was 25.77%(260/1009).Multivariate analysis showed that gender(OR=1.338,P=0.006),height(OR=1.993,P=0.001),frequency of iodine-rich food intake(OR=0.862,P=0.048)and nutritional supplements(OR=1.469,P=0.008)were correlated with the prevalence of thyroid nodules.Conclusion The prevalence rate of thyroid nodules in children aged 8-10 years old in Suzhou is 23.34%.Female gender,higher height,regular intake of iodine-rich foods and dietary supplements are statistically associated with the prevalence of thyroid nodules,which may be risk factors for the prevalence of thyroid nodules,but further research is needed to confirm.