成都市新都区成人自身免疫性甲状腺炎危险因素的病例对照研究

Case-control study of risk factors for autoimmune thyroiditis in adults in the Xindu region

目的探究新都地区成人自身免疫性甲状腺发病影响因素,为预防自身免疫性甲状腺炎的发生提供依据。方法采用病例对照研究方法,选择成都市新都区中医医院2016—2020年收治的581例自身免疫性甲状腺炎患者作为观察组,同期体检健康者450例作为对照组,获取两组人相关资料并采用单因素和多因素logistic回归模型分析成人自身免疫性甲状腺发病影响因素。结果单因素结果显示观察组体重指数≥30.0 kg/m^(2)、高脂血症、代谢综合征和尿碘(<100μg/L及>200μg/L)占比高于对照组,甲状腺功能[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)]、自身甲状腺抗体[甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)、]大于对照组(P<0.05)。经logistic回归分析得到,体重指数≥30.0、TGAb阳性、TPOAb阳性、高脂血症及代谢综合征是成人自身免疫性甲状腺炎独立危险因素[OR(95%CI):1.965(1.340~3.129)、3.362(1.568~8.243)、3.089(1.753~7.166)、2.507(1.164~4.956)、2.218(1.207~3.362),P<0.05]。结论体重指数≥30.0 kg/m^(2)、高脂血症及代谢综合征是导致新都地区成人自身免疫性甲状腺炎危险因素。控制体重,控制高脂血症和代谢综合征,大力宣传自身免疫性甲状腺炎防治,是降低新都地区成人自身免疫性甲状腺炎关键。

Objective To explore the influencing factors of autoimmune thyroid disease in Xindu region and provide a basis for preventing the occurrence of autoimmune thyroiditis.Methods Using case-control study,581 autoimmune thyroid patients treated in 2016-2020 in Chengdu Xindu District Hospital of 2020,and 450 healthy patients were selected as the control group.Relevant data were obtained and the influencing factors of adult autoimmune thyroid disease were analyzed by univariate and multivariate logistic regression model.Results Univariate results showed that the observed BMI of 30.0 kg/m^(2),hyperlipidemia,metabolic syndrome and urinary iodine(<100μg/L and>200μg/L)were higher than control group,with thyroid function[free triiodinated thyrigenine(FT3),free thyroxine(FT4)and thyroid stimulating hormone(TSH)),autothyroid antibody[thyroglobulin antibody(TGAb),antithyroid peroxidase antibody(TPOAb),]greater than control group(P<0.05).According to logistic regression analysis,body mass index 30.0,TGAb positive,TPOAb positive,hyperlipidemia,and metabolic syndrome were independent risk factors for adult autoimmune thyroiditis[OR(95%CI):1.965(1.340),3.1262(1.568-8.243),3.089(1.753-7.166),2.507(1.164-4.956),2.218(1.207-3.362),P<0.05].Conclusion Body mass index of 30.0 kg/m^(2),hyperlipidemia and metabolic syndrome are the risk factors for adult autoimmune thyroiditis in Xindu region.Controlling weight,controlling autoimmune thyroiditis and metabolic syndrome are the key to reducing adult autoimmune thyroiditis in Xindu region.