脂肪因子在非酒精性脂肪性肝病中研究进展

Progress on adipokines in non-alcoholic fatty liver disease

脂肪因子在单纯性脂肪肝(non-alcoholic simple fatty liver,NAFL)、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)、肝纤维化、肝硬化乃至肝癌的发生发展过程中发挥重要作用。对脂肪因子及其信号转导途径的研究有助于非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的诊断及治疗新靶点的挖掘。本文通过对瘦素、脂联素、趋化素、抵抗素、Nrg4、SDF-1、EPDR1、IL6/IL27及isthmin-1等脂肪因子的综述探讨NAFLD相关脂肪因子及其信号通路研究的新进展。

Adipokines play an important role in the development of non-alcoholic simple fatty liver(NAFL),non-alcoholic steatohepatitis(NASH),liver fibrosis,liver cirrhosis and even liver cancer.The studies in adipokines and their signal transduction pathways will contribute to diagnosing and digging new therapeutic targets for non-alcoholic fatty liver disease(NAFLD).This paper explored new progress in the study of adipokines associated with NAFLD and their signal pathways through reviewing leptin,adiponectin,chemerin,resistin,Nrg4,SDF-1,EPDR1,IL6/IL27,isthmin-1 and so on.