乙型肝炎相关慢加急性肝衰竭发病机制及治疗进展

Progress on pathogenesis and medical treatment of hepatitis B virus-related chronic and acute liver failure

乙型肝炎相关慢加急性肝衰竭(hepatitis B virus-related acute-on-chronic liver failure,HBV-ACLF)是一种短期病死率极高的临床综合征,其发病机制尚不完全明确,除肝移植外尚无有效的治疗措施。肝移植常受限于肝源不足、治疗费用高昂等因素,因此内科综合治疗(包括人工肝支持系统)就成为提高患者短期生存率的重要手段。本文将重点阐述HBV-ACLF的发病机制及内科综合治疗相关进展。

Hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF)is a complicated syndrome with extremely high short-term mortality.The pathogenesis of HBVACLF has not been fully elucidated,and there is no effective treatment except for liver transplantation.Liver transplantation is limited by the shortage of donor livers and high costs of the treatment.Thus,the comprehensive medical treatment(including artificial liver support systems)emerged as an important intervention for improving short-term survival of patients with HBV-ACLF.This paper focuses on the pathogenesis of HBV-ACLF and recent progress of comprehensive medical treatment.