类鼻疽伯克霍尔德菌致病及耐药机制

Pathogenesis and drug resistance mechanism of Burkholderia pseudomallei

类鼻疽伯克霍尔德菌是导致类鼻疽的病原菌。类鼻疽慢性感染时间长,急性起病时临床表现不典型、易发生危及生命的并发症、预后不佳。研究病原菌类鼻疽伯克霍尔德菌的致病及耐药机制将有效帮助疾病的诊疗,改善预后。本文从类鼻疽伯克霍尔德菌在宿主细胞外运动的形式、感染宿主细胞的方式、毒力因子、耐药机制(外排泵、靶位点改变等)等方面阐述。为该菌所致类鼻疽的早期诊治及控制提供可能的方向。

Burkholderia pseudomallei is the pathogen that causes melioidosis.Melioidosis has a long duration of chronic infection,atypical clinical manifestations at acute onset,and is prone to life‑threatening complications and poor prognosis.Understanding the pathogenesis and drug resistance mechanism of Burkholderia pseudomallei will effectively help the diagnosis and treatment of the disease and improve the prognosis.This review focuses on the extracellular movement of Burkholderia pseudomallei in host cells,the way of infecting host cells,virulence factors,and drug resistance mechanisms(efflux pumps,changes in target sites,etc.).This study provides a possible direction for the early diagnosis,treatment and control of melioidosis caused by this bacterium.