银屑病合并代谢性疾病发病机制的研究进展

Advances on pathogenesis of psoriasis complicated with metabolic diseases

银屑病是一种常见的由免疫介导的慢性炎症性皮肤病,其发病机制与遗传、免疫、感染、环境等多种因素有关。近年来,银屑病患者合并代谢性疾病的发病率显著增高,大量国内外研究表明,银屑病与代谢性疾病之间可能存在着共同的发病机制,尤其包括炎症因子、脂肪因子、易感基因等的参与。深入了解银屑病合并代谢性疾病的发病机制对于银屑病的治疗与合并症的预防具有重要的指导意义。

Psoriasis is a common immune-mediated chronic inflammatory skin disease,and its pathogenesis is related to genetic,immune,infectious,environmental,and other factors.In recent years,the incidence of psoriasis complicated with metabolic diseases has increased significantly.A large number of domestic and foreign studies have shown that there may be common pathogenesis between psoriasis and metabolic diseases,especially involving inflammatory factors,adipokines,and susceptibility genes.A thorough understanding of pathogenesis of psoriasis complicated with metabolic diseases is of great significance for the treatment of psoriasis and the prevention of its complications.