骨肉瘤临床治疗现状与创新疗法研究进展

Research progress on clinical treatment and innovative therapy of osteosarcoma

骨肉瘤(osteosarcoma,OS)是一种发生在骨组织中的高度恶性肿瘤,具有很高的转移倾向,其潜在机制在很大程度上仍不清楚。OS临床治疗预后较差,提高OS患者的生存率仍然是一个挑战。近年来,随着分子生物学和组织生物工程的发展,治疗方法也取得了迅速的进步,特别是在综合保肢治疗方面,显著提高了术后生活质量,提高了恶性肿瘤患者的5年生存率。本文对OS从手术、化学疗法和免疫疗法等方面进行综述,为当前OS的临床治疗提供参考。

Osteosarcoma(OS)is a highly malignant tumor occurring in bone tissue with a high tendency to metastasize,the underlying mechanism of which is still largely unknown.Clinical treatment of OS has a poor prognosis,and improving the survival rate in patients with OS remains a challenge.In recent years,with the development of molecular biology and tissue bioengineering,treatment methods have also made rapid progress,especially in the aspect of comprehensive limb salvage therapy,which significantly improves the postoperative quality of life and 5-year survival rate in patients with malignant tumors.This article reviews the surgical method,chemotherapy,and immunotherapy of OS,to provide reference for the current clinical treatment of OS.