摘要
铜绿假单胞菌(Pseudomonas aeruginosa, PA)是临床常见的革兰阴性菌之一,分布广泛且可引起多种感染。PA可分泌大量的毒力因子,包括脂多糖(lipopolysaccharide, LPS)、鼠李糖脂(rhamnolipid)、外毒素A(exotoxin A)、蛋白酶(proteinase)、生物膜(biofilm)和Ⅲ型分泌系统(type III secretion system, T3SS)等,且PA毒力机制较复杂。在PA感染过程中,群体感应系统(quorum-sensing, QS)和双组分系统(two-component systems, TCS)扮演着重要的角色,调控PA生物膜的形成和毒力因子的产生。现就PA毒力因子的研究进展及调控机制作一概述。
Pseudomonas aeruginosa(PA) is one of the most common Gram-negative bacilli in clinical practice, which is widely distributed and can cause a variety of infections. PA can secrete a large number of virulence factors, including lipopolysaccharide(LPS), rhamnolipid, exotoxin A, proteinase, biofilm and type III secretion system(T3SS), and the mechanism of virulence regulation in PA is also complex. The quorum-sensing(QS) system and two-component systems play an important role in the pathogenesis of PA, mediating PA biofilm formation and virulence factor production. In this paper, we review the discovery and regulatory mechanisms of PA virulence factors.
作者
何媛
宋贵波
HE Yuan;SONG Gui-bo(Department of Clinical Laboratory,the First Affiliated Hospital of Kunming Medical University,Yunnan Key Laboratory of Laboratory Medicine,Yunnan Province Clinical Research Center for Laboratory Medicine,Kunming 650032,Yunnan Province,China)
出处
《微生物学免疫学进展》
CAS
2023年第2期94-99,共6页
Progress In Microbiology and Immunology
基金
云南省“高层次人才培养支持计划”青年拔尖人才项目(YNWR-QNBJ-2020-261)
云南省医学后备人才培养计划项目(H-2018075)。
关键词
铜绿假单胞菌
毒力因子
Ⅲ型分泌系统
生物膜
群体感应系统
双组分系统
调控
Pseudomonas aeruginosa
Virulence factor
Type III secretion system
Biofilm
Quorum sensing system
Two-component systems
Regulation
