胶质纤维酸性蛋白、泛素羧基端水解酶L1联合卒中量表评分在急性脑梗死预后评估中的应用研究

Application of glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase L1 combined with NIH stroke scale in the prognosis evaluation of acute cerebral infarction

目的探讨胶质纤维酸性蛋白(GFAP)、泛素羧基端水解酶L1(UCH-L1)联合美国国立卫生研究院卒中量表(NIHSS)对急性脑梗死(ACI)预后的预测价值。方法收集我院124例ACI患者资料(ACI组)及66例正常人(健康组)。比较两组GFAP、UCH-L水平变化;分析不同预后ACI患者GFAP、UCH-L水平及与NIHSS评分的关系;探讨上述指标在ACI治疗预后评估中的价值。结果ACI组GFAP、UCH-L水平及NIHSS评分显著高于健康组,预后良好组GFAP、UCH-L水平及NIHSS评分显著低于预后不良组(P<0.05)。GFAP、UCH-L水平与NIHSS评分、mRS评分均呈正相关关系(P<0.05)。ROC结果示,GFAP、UCH-L及NIHSS评分联合检测AUC为0.774,明显高于各项指标单独检测(P<0.05)。结论GFAP、UCH-LI、NIHSS评分可作为评估ACI患者预后的参考指标,且上述指标联合预测价值更高。

Objective To explore the predictive value of glial fibrillary acidic protein(GFAP)and ubiquitin carboxy-terminal hydrolase L1(UCH-L1)combined with National Institutes of Health Stroke Scale(NIHSS)on the prognosis of acute cerebral infarction(ACI).Methods Data of 124 patients with ACI(ACI group)and 66 normal persons were collected in our hospital.The changes in the levels of GFAP and UCH-L1 were compared between the two groups.The relationship between the levels of GFAP and UCH-L1 and the NIHSS scores in the ACI patients with different prognosis was analyzed.The value of the above indicators in the ACI treatment prognosis evaluation was explored.Results The levels of GFAP,UCH-L1 and NIHSS scores in the ACI group were significantly higher than those in the healthy group,while the levels of GFAP,UCH-L1 and NIHSS scores in the group with good prognosis were significantly lower than those in the group with poor prognosis(P<0.05).The levels of GFAP and UCH-L1 were positively correlated with the scores of NIHSS and Modified Rankin Scale(mRS)(P<0.05).ROC results showed that the area under curve(AUC)of combined detection of GFAP,UCH-L and NIHSS scores was 0.774,that was significantly higher than that of single detection of each index(P<0.05).Conclusions GFAP,UCH-LI and NIHSS scores can be used as reference indexes to evaluate the prognosis of ACI patients.The predictive value of above combined indicators is higher.