血小板内皮聚集受体1及其介导的信号通路在血小板和内皮细胞中的作用研究进展

Platelet-endothelial aggregation receptor 1 and its mediated signalling pathway Advances in the study of the role of platelets and endothelial cells

血小板内皮聚集受体1(platelet endothelial aggregation receptor 1, PEAR1)是2005年被发现的一种跨膜受体,主要在血小板和内皮细胞上表达。PEAR1是血小板与血小板间相互接触的受体蛋白,在血小板活化和聚集过程中起着重要作用。内皮细胞在维持血管张力和血管修复方面发挥重要作用,PEAR1通过影响其增殖和相关新生血管的形成,调控肿瘤的发生、发展过程。近年来,PEAR1逐渐被公认为是抗血栓药物的潜在靶点。本综述主要阐明血小板内皮聚集受体1在血小板和内皮细胞中的作用机制以及相关信号通路,为肿瘤相关血栓的药物治疗研究提供新思路。

Platelet-aggregation receptor 1(PEAR1)is a transmembrane receptor identified in 2005 and expressed mainly on platelets and endothelial cells.PEAR1 is a receptor protein that contacts platelets with each other and plays an important role in platelet activation and aggregation.Endothelial cells play an important role in maintaining vascular tone and vascular repair,and PEAR1 regulates the process of tumourigenesis and development by affecting their proliferation and associated neovascularisation.In recent years,PEAR1 has gradually been recognized as a potential target for antithromboticdrugs. This review focuses on elucidatingthe mechanisms of platelet endothelial aggregationreceptor 1 and related signaling pathways inplatelets and endothelial cells, and provides newideas for the study of drug therapy for tumour-associatedthrombosis.