2型糖尿病老年患者用药依从性与糖化血红蛋白控制的相关性分析

Correlation Between Medication Compliance and Glycosylated Hemoglobin Control in Elderly Patients with Type 2 Diabetes Mellitus

目的:分析2型糖尿病(T2DM)老年患者用药依从性与糖化血红蛋白(HbA1c)控制的相关性。方法:选取2017年8月—2018年8月我院收治的450例老年T2DM患者为研究对象,调查受试对象用药依从性情况,并采用单因素及多因素Logistic回归分析T2DM患者用药依从性影响因素,分析用药依从性与HbA1c之间的相关性。结果:450例老年T2DM患者用药依从性评分平均为(18.57±1.35)分,其依从性水平欠佳;其中,66.22%患者用药依从性差,33.78%患者依从性好;经单因素及多因素Logistic回归分析显示,病程、文化程度、职业状况、家庭经济状况、社会支持情况、用药频次、用药种类是老年T2DM患者用药依从性较差的影响因素(P<0.05);用药依从性好患者血清HbAlc水平低于用药依从性差患者,(P<0.05)。经Pearson相关性分析显示,用药依从性与HbA1c水平呈负相关(r=-0.245,P<0.05)。结论:老年T2DM患者用药依从性水平欠佳,用药依从性与HbA1c水平呈负相关,可作为评估HbAlc控制情况的工具,为老年T2DM治疗、健康教育等提供科学依据。

Objective:To analyze the correlation between medication compliance and glycosylated hemoglobin(HbAlc)control in elderly patients with type 2 diabetes mellitus(T2DM).Methods:A total of 450 elderly patients with T2DM who were admitted to People's Hospital of Wanning,Hainan Province from August 2017 to August 2018 were selected as the study subjects.Medication compliance of the subjects was investigated.Univariate analysis and multivariate Logistic regression analysis were performed to screen the factors influencing medication compliance of patients with T2DM.The correlation between medication compliance and HbAlc was analyzed.Results:In this study,the average score of medication compliance was(18.57±1.35)scores,indicating that compliance was not good.Among the subjects,66.22%of patients had poor medication compliance and 33.78%of patients had good compliance.The results of univariate analysis and multivariate logistic regression analysis showed that the course of disease,education level,occupational status,family economic status,social support,medication frequency and type of the drug used were influencing factors of poor medication compliance of elderly patients with T2DM(P<0.05).Serum HbAlc level of patients with good drug compliance was lower than that of patients with good drug compliance(P<0.05).Pearson correlation analysis showed that medication compliance was negatively correlated with HbA1c level(r--0.245,P<0.05).Conclusion:Elderly patients with T2DM have poor medication compliance,and medication compliance is negatively correlated with HbAlc level.Therefore,medication compliance can be used as a tool to evaluate the control of HbA1c,thus providing a scientific basis for the treatment and health education of elderly T2DM.