非那雄胺治疗排尿障碍的疗效与不良反应分析

Efficacy and Adverse Reactions of Finasteride in the Treatment of Dysuria

目的:探讨非那雄胺治疗排尿障碍的疗效与不良反应。方法:选取2020年1月—2022年1月我院治疗的良性前列腺增生导致排尿障碍患者110例作为研究对象,根据抽签法分为分析组和对照组,每组55例。分析组采用非那雄胺治疗,对照组采用盐酸坦洛新治疗,比较两组临床症状、泌尿功能、治疗效果以及不良反应发生情况。结果:治疗后,两组国际前列腺症状评分(I-PSS)、泌尿症状困扰评分表(BS)评分、排尿期症状评分低于治疗前,且分析组低于对照组(P<0.05);两组残余尿量、最大尿流量、前列腺体积高于治疗前,且分析组高于对照组(P<0.05);分析组生活质量指数(QOL)评分低于对照组,排尿功能恢复时间短于对照组(P<0.05);分析组不良反应发生率低于对照组(P<0.05)。结论:非那雄胺可显著改善患者的临床症状和泌尿功能,提升患者的治疗效果,且不良反应发生率更低,安全性较高。

Objective:To explore the efficacy and adverse reactions of finasteride in the treatment of dysuria.Methods:A total of 110 patients with benign prostatic hyperplasia leading to urination disorder treated in our hospital from January 2020 to January 2022 were selected as the research objects,and divided into analysis group and control group according to the lottery method,with 55 cases in each group.The analysis group was treated with finasteride,and the control group was treated with tamsulosin hydrochloride.The clinical symptoms,urinary function,treatment effect and occurrence of adverse reactions were compared between the two groups.Results After treatment,the International Prostate Symptom Score(I-PSS),Urinary Symptom Trouble Score(BS)score,and voiding symptom score in the two groups were lower than those before treatment,and the analysis group was lower than the control group(P<0.05);the residual urine volume,maximum urine flow and prostate volume in the two groups were higher than those before treatment,and the analysis group was higher than the control group(P<0.05);the quality of life index(QOL)score of the analysis group was lower than that of the control group,and the recovery time of urination function was shorter than that of the control group(P<0.05);the incidence of adverse reactions in the analysis group was lower than that in the control group(P<0.05).Conclusion:Finasteride can significantly improve the clinical symptoms and urinary function of patients,improve the therapeutic effect of patients,and has a lower incidence of adverse reactions and higher safety.