盐酸美金刚治疗帕金森痴呆患者的临床疗效分析

Clinical Efficacy of Memantine Hydrochloride in the Treatment of Parkinson's Disease

目的探讨在针对帕金森痴呆患者的治疗过程之中,使用盐酸美金刚药物联合服用的临床疗效。方法选取2020年1月-2022年10月纳入治疗的帕金森痴呆患者84例,根据不同用药方案将患者分为对照组42例与观察组42例,对照组患者予以盐酸多奈哌齐治疗,观察组则在对照组基础上联合盐酸美金刚治疗,比较两组患者治疗效果。结果观察组患者总有效率为95.24%高于对照组78.57%(P<0.05)。治疗后,观察组患者的MOCA、MMSE量表评分高于对照组患者(P<0.05),且治疗后观察组患者的ADL量表评分优于对照组(P<0.05)。两组患者不良症状发生率相当,(P>0.05)。结论在针对帕金森痴呆患者的治疗过程之中,使用盐酸美金刚药物联合服用,不但效果明显有所提高,还可促进日常生活能力和认知功能的恢复,且治疗安全性高。

Objective to investigate the clinical efficacy of memantine hydrochloride in the treatment of Parkinson's dementia.Methods eighty-four patients with Parkinson's disease were selected from January 2020 to October 2022.They were divided into control group(n=42)and observation group(N=42),the patients in the control group were treated with DONEPEZIL hydrochloride,while the patients in the observation group were treated with memantine hydrochloride on the basis of the control group.The therapeutic effects of the two groups were compared.Results the total effective rate was 96.15%in the observation group and 76.92%in the control group(P&Lt;0.05).After treatment,the scores of MOCA and MMSE in the observation group were significantly higher than those in the control group(P&Lt;0.05),and the scores of ADL in the observation group were significantly higher than those in the control group(P&Lt;0.05).There was no significant difference in the incidence of adverse symptoms between the two groups(P>0.05).Conclusions the combination of donepezil and memantine can improve the therapeutic effect,improve the cognitive function and ability of daily living of the patients with Parkinson's dementia,and the treatment is safe.