代谢组学在糖尿病肾病早期诊断中的研究进展

Research progress of metabonomics in early diagnosis of diabetic kidney disease

糖尿病肾病作为糖尿病常见的并发症,是导致终末期肾病的主要原因之一。由于其病程进展迅速,加之治疗手段有限,因此,从早期实验诊断入手寻找生物标志物对于糖尿病肾病的治疗具有重要临床意义。目前,早期诊断糖尿病肾病的方法有限;而代谢组学作为一种应用较广泛的研究方法,可以检测疾病中的代谢产物,为疾病的诊断和预后提供生物标志物。该文对糖尿病肾病患者血液或尿液内氨基酸、脂质、有机酸等代谢物质的变化进行了归纳总结。

Diabetic kidney disease,as a common complication of diabetes,is one of the main causes of end-stage renal disease.Because of the rapid progress of its course and the limited means of treatment,it is of great clinical significance to seek biomarkers from early diagnosis for the treatment of diabetic kidney disease.At present,there are limited methods for early diagnosis of diabetic kidney disease.As a widely used research method,metabonomics can detect metabolites in diseases and provide biomarkers for disease diagnosis and prognosis.This article summarizes the changes of amino acids,lipids,organic acids and other metabolites in blood or urine of patients with diabetic kidney disease.