在代际传递背景下影响子代过敏性疾病易感性的研究进展

Research progress on effects of intergenerational transmission on allergic disease susceptibility in offspring

过敏性疾病是由机体对抗原所产生的异常免疫反应引发的疾病,近年来儿童过敏性疾病的患病率呈上升趋势,已经成为当今社会迫切解决的公共卫生问题之一。最近临床数据和研究表明,代际传递因素与儿童患过敏性疾病的易感性有关,母代在孕前或孕期遭受一些不利因素可能会使其子代患过敏性疾病的易感性增强。因此识别早期危险因素(即母代危险因素)对于儿童过敏性疾病的预防具有重要意义。目前在代际传递背景下影响子代过敏性疾病易感性的研究取得了一定的进展,关于其分子生物学机制已有初步探究,该文针对母代遭受不利因素对子代患过敏性疾病的易感性的影响进行综述,以期在代际传递背景下为儿童过敏性疾病的预防提供新的方法和思路。

Allergic diseases are diseases caused by abnormal immune responses to antigens.Recently the prevalence of allergic diseases in children is on the rise,which has become one of the urgent public health problems to date.Recent clinical data and research show that the susceptibility of allergic diseases in offspring is inextricably associated with intergenerational transmission factors.Some unfavorable factors suffered by mothers before or during pregnancy may increase the allergic disease susceptibility in offspring.Therefore,it is of great significance to identify early risk factors(mother’s generation)for the prevention of allergic diseases in children.At present,under the background of intergenerational transmission,some progress has been made in the research on the susceptibility of allergic diseases in offspring,and some researches have elucidated the potential molecular biological mechanisms.The current review summarizes the effects of maternal pregestational and prenatal unfavorable factors on the susceptibility of allergic diseases in offspring.