1970—2019年广东省中山市多原发恶性肿瘤发病分析

Incidence of Multiple Primary Cancers in Zhongshan City of Guangdong Province,1970—2019

[目的]分析1970—2019年中山市多原发恶性肿瘤发病资料,为中山市多原发恶性肿瘤的预防和控制提供科学依据。[方法]收集和整理1970—2019年中山市人群肿瘤登记资料中多原发恶性肿瘤的发病资料,分析研究其不同时段、性别、年龄和部位的发病数、比和率等。[结果]1970—2019年中山市发生了5369例多原发恶性肿瘤,占中山市同期恶性肿瘤发病总数的5.00%,发病粗率、中标率和世标率分别为8.60/10万、6.62/10万和8.62/10万,2重和3重多原发恶性肿瘤分别占同期中山市多原发恶性肿瘤发病总数的94.06%和5.31%,非同时发生多原发恶性肿瘤占75.79%。总体而言,最常见多原发恶性肿瘤发病部位和系统分别是胸和腹部、消化和呼吸系统,最常见第1原发肿瘤为结直肠癌和鼻咽癌,最常见多原发恶性肿瘤组合是结直肠-结直肠。1970—2019年中山市多原发恶性肿瘤发病明显上升,从35岁左右迅速上升,至75~79岁年龄组达高峰,不同时段年龄别发病模式基本相同。[结论]1970—2019年中山市多原发恶性肿瘤发病虽位于全球较低水平,但明显上升。胸和腹部、消化和呼吸系统是中山市最常见多原发恶性肿瘤发病部位和系统,鼻咽癌是中山市常见多原发恶性肿瘤,提示中山市应加强多原发恶性肿瘤的防治。

[Purpose]To analyze the incidence of multiple primary cancers(MPCs)in Zhongshan City of Guangdong Province during 1970—2019.[Methods]The MPCs incidence data in Zhongshan City during 1970—2019 were collected from population-based Zhongshan cancer registry.The incidence number,composition and rates by periods,gender,age and sites were calculated and analyzed.[Results]There were 5369 cases of MPCs,accountig for 5.00%of total new cancer cases,occurred in Zhongshan City during 1970—2019.The crude incidence rate was 8.60/105,age-standardized rates by Chinese and world standard population were 6.62/105,and 8.62/105,respectively.Among all cases 94.06%and 5.31%were double and triple primary cancers,and 75.79%of them occurred metachronously.MPCs in Zhongshan City occurred mostly in chest and abdomen,or in digestive and respiratory systems,and the most common index primary cancers were colorectal and nasopharyngeal cancers,the most frequent MPCs combination was colorectumcolorectum.The incidence of MPCs in Zhongshan City showed a significant increasing trend during the period,and its age-specific incidence rose from 35 years of age and peaked at the age group of 75~79 years in all time periods.[Conclusion]The incidence of MPCs in Zhongshan City during 1970—2019 was at a low level worldwide,however it increased remarkably.Chest and abdomen,digestive and respiratory systems were the most common sites and systems for MPCs,and nasopharyngeal cancer was one of the common MPCs in Zhongshan City during 1970—2019.It suggests that MPCs prevention and control in Zhongshan City should be enhanced accordingly.