cGAS-STING信号通路在脑肿瘤中的研究进展

Recent advance in role of cyclic GMP-AMP synthase-stimulator of interferon gene signal pathway in brain tumors

环鸟苷酸-腺苷酸合成酶(cGAS)-干扰素基因刺激因子(STING)信号通路是STING激活的经典途径,其在激发天然免疫方面的作用近年来逐渐被广泛关注。cGAS可识别并结合内源性或外源性DNA,催化三磷酸腺苷(ATP)和三磷酸鸟苷(GTP)合成环鸟苷酸-腺苷酸(cGAMP),继而激活STING信号,促进Ⅰ型干扰素(IFN)和炎性因子的产生,诱导天然免疫和适应性免疫。现有研究表明,cGAS-STING信号通路在感染、炎症、肿瘤等的治疗中发挥着重要作用,尤其是在临床治疗效果欠佳的高级别胶质瘤的治疗中也有着巨大潜力。本文将对cGAS-STING信号通路做简要概述并总结其在脑肿瘤中的作用及机制,以期为脑肿瘤治疗靶点和治疗药物的发掘提供新思路。

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon gene(STING)signal pathway is a classical pathway of STING activation,and in recent years,its role in stimulating innate immunity has gradually attracted wide attention.Besides,cGAS can recognize and combine endogenous or exogenous DNA,then catalyze ATP and GTP to synthesize cyclic guanosine monophosphate-adenosine monophosphate(cGAMP),subsequently activate STING signal to promote type I interferon and inflammatory factors,finally induce natural and adaptive immunity.Existing studies have indicated that cGAS-STING signal pathway plays an important role in infections,inflammations and tumors,especially in high-grade gliomas with poor clinical treatment efficacy.Here,we briefly summarize the cGAS-STING signal pathway and its mechanism in brain tumors to provide new ideas for exploring therapeutic targets and drugs for brain tumors.