营卫理论在轻度认知障碍病机研究中的应用

Application of Ying-Wei Theory in Studying the Pathogenesis of Mild Cognitive Impairment

轻度认知障碍是指以记忆力或其他认知功能进行性减退为主要临床表现的中枢神经退行性疾病,是正常认知与痴呆的过渡阶段。中医将轻度认知障碍归于健忘、善忘、痴呆等病的范畴,病位主要在心、脑,病机与营卫运行失调密切相关。营卫实质及功能与神经血管单元存在多重联系。现根据营气与神经元细胞、星形胶质细胞在功能上的相似性,以及卫气与血脑屏障、小胶质细胞的相关性,提出营卫运行失调是轻度认知障碍的重要病机,病机包括“营弱卫强”和“卫虚营滞”,造成神经血管单元功能紊乱和结构改变,脑神衰退,认知障碍。拓展营卫理论在脑病的应用,加强营卫理论在神志疾病中的探索,以期为中医药防治轻度认知障碍提供新思路。

Mild cognitive impairment refers to a degenerative disease of the central nervous system,with a progressive decline of memory or other cognitive functions as the main clinical manifestations.It is a transitional stage between normal cognition and dementia.In traditional Chinese medicine,mild cognitive impairment is classified as amnesia,forgetfulness,dementia,and other diseases.The location of the disease is mainly in the heart and brain,and the pathogenesis is closely related to the disharmony between Ying and Wei circulation.There are multiple relationships between the essence of Ying-Wei and neurovascular units.According to the functional similarity among Ying Qi,neurons,and astrocytes,and the correlation among Wei Qi,blood brain barrier,and microglia cells,it is pointed out that the disharmony between Ying and Wei circulation is important pathogenesis of mild cognitive impairment,including“weak Ying and strong Wei”and“weak Wei and Ying stagnation”,which results in neurovascular unit dysfunction and structural changes,brain decline,and cognitive impairment.Therefore,it is necessary to expand the application of Ying-Wei theory in encephalopathy and strengthen the exploration of Ying-Wei theory in mental diseases,so as to provide new ideas for the prevention and treatment of mild cognitive impairment with traditional Chinese medicine.