维生素D联合卤米松治疗25-羟维生素D_(3)低下轻中度斑秃疗效观察

Efficacy of vitamin D combined with halomethasone in the treatment of mild to moderate alopecia areata with low 25-hydroxyvitamin D_(3)

目的观察口服维生素D联合卤米松乳膏外用治疗25-羟维生素D_(3)[25-(OH)D_(3)]低下轻中度斑秃(AA)的疗效。方法将2019年4月至2021年4月遵义医科大学第三附属医院收治的45例25-(OH)D_(3)低下的AA患者随机分为2组。对照组(n=21)患者外用卤米松乳膏每天2次,研究组(n=24)患者在外用卤米松乳膏基础上,每天口服维生素D滴剂,治疗12周后分析2组患者总有效率、不良反应及短期复发情况。结果研究组总有效率为87.5%,高于对照组的61.9%,差异有统计学意义(P<0.05)。2组均未发生严重的不良反应。研究组无短期复发,对照组复发3例,2组复发率比较,差异有统计学意义(P<0.05)。结论口服维生素D滴剂联合卤米松乳膏治疗25-(OH)D_(3)低下的AA疗效显著,且无明显不良反应,复发率低。

Objective To observe the clinical efficacy of oral vitamin D combined with topical halometasone cream in the treatment of mild to moderate alopecia areata(AA)with low 25-hydroxyvitamin D_(3)[25-(OH)D_(3)].Methods A total of 45 AA patients with low 25-(OH)D_(3)admitted to the Third Affiliated Hospital of Zunyi Medical University from April 2019 to April 2021 were randomly divided into the two groups.The patients in the control group(n=21)were given the therapy of topical halometasone cream twice a day,while the patients in the study group(n=24)were treated with oral vitamin D drops daily on the basis of topical halometasone cream.After 12 weeks of treatment,the efficacy,adverse reaction and short-term recurrence of the patients in the two groups were analyzed.Results The effective rate of the study group was 87.5%,higher than 61.9%of the control group,with statistically significant difference(P<0.05).No serious adverse reactions occurred in both groups.There was no short-term recurrence in the study group,while three cases in the control group.There was a statistically significant difference in recurrence rate between the two groups(P<0.05).Conclusion The combination therapy of oral vitamin D drops and halometasone cream for AA with mild 25-(OH)D_(3)has significant efficacy,and there is no obvious adverse reaction and low recurrence rate..