斑马鱼肝纤维化动物模型研究进展

Application and progress of zebrafish in the study of liver fibrosis

斑马鱼因胚胎光学透明、发育快以及药物可以通过皮肤和鳃渗入体内等原因,被广泛应用于肝疾病的相关研究。肝纤维化(hepatic fibrosis,HF)是指由各种致病因子所致的肝内结缔组织异常增生的一种病理生理变化,许多慢性肝病均可引起HF。由于斑马鱼HF发生所涉及的信号传导机制与人类相似,目前已成功构建斑马鱼肝纤维化模型。本文论述国内外斑马鱼HF模型研究的相关成果和肝纤维化治疗药物筛选的现状,旨在为探索肝纤维化发病机制、寻找HF治疗药物及斑马鱼HF模型的合理应用提供指导。

Zebrafish are widely used in liver disease research because of the optical transparency of embryos,rapid development,and drug penetration into the body through the skin and gills.Hepatic fibrosis(HF)is a pathophysiological change in abnormal proliferation of connective tissue in the liver caused by various pathological factors.HF can be caused by many chronic liver diseases.Because the signaling mechanism involved in the occurrence of HF in zebrafish is similar to that in humans,a zebrafish liver fibrosis model has been successfully established.This article discusses the relevant result of zebrafish HF model research and the current status of drug screening for liver fibrosis therapy domestically and abroad to provide guidance for research into the pathogenesis of liver fibrosis,screening for drug treatments of HF,and rational application of the zebrafish HF model.