化疗药物诱导的神经病理性疼痛动物模型研究进展

Advances in animal models of chemotherapy-induced peripheral neuropathy pain

化疗药物诱导的神经病理性疼痛(chemotherapy-induced peripheral neuropathy pain,CIPNP)严重影响癌症患者生活质量及治疗进程,但其机制不明,故缺乏有效治疗手段。动物模型是研究CIPNP的重要工具,在发病机制及治疗方法的研究中发挥着极其重要的作用。本文综述了近5年来CIPNP动物模型的研究现状,分析了几种常见造模方法的优缺点,并对其发病机制进行了介绍。本文旨在为今后研究者选择更为有效的动物实验模型提供参考,此外为其治疗提供新思路。

Chemotherapy-induced peripheral neuropathy pain(CIPNP)seriously affects quality of life and treatment of cancer patients,but its mechanism is unknown and there is no effective therapy.Animal models are important to study CIPNP and play an extremely important role in the study of pathogenesis and treatments.This article reviews the research status of CIPNP animal models in the previous 5 years,analyzes the advantages and disadvantages of several common modeling method,and introduces its pathogenesis.This review aims to provide a reference for researchers to choose more effective animal experimental models and new ideas for treatment.