远志地上部分正丁醇部位化学成分研究

Chemical Constituents of n-Butanol Fraction from Aerial Part of Polygala tenuifolia

目的:研究远志Polygala tenuifolia Wild.地上部分的化学成分。方法:远志地上部分70%乙醇提取物的正丁醇萃取部位采用硅胶、中压十八烷基键合硅胶(ODS)色谱柱和高效液相色谱法(HPLC)进行分离纯化,根据理化性质和核磁共振波谱数据鉴定化合物的结构。结果:从远志地上部分70%乙醇提取物的正丁醇萃取部位中分离得到13个化合物,分别为顺式丁香苷(1)、长春花苷Ⅱ(2)、2-苯乙醇-β-D-葡萄糖苷(3)、吐叶醇(4)、4-C-[β-D-呋喃芹菜糖基-(1→6)-β-D-吡喃葡萄糖基]-1,3,6-三羟基-7-甲氧基氧杂蒽酮苷(5)、蚱蜢酮(6)、3-羟基-1-(4-羟基-3-甲氧基苯基)丙烷-1-酮(7)、polygalatenoside A(8)、刺槐林素(9)、3′,5′-二甲氧基双苯基-4-醇(10)、拟茎点霉内酯A(11)、莽吉柿酮D(12)和玫红穗状霉胺A(13)。结论:化合物2、4、6、7、9~13均为首次从远志科植物中分离得到。

Objective:To study the chemical constituents from the aerial part of Polygala tenuifolia Wild..Methods:The n-butanol fraction of the 70%ethanol extract from the aerial part of P.tenuifolia was isolated and purified by silica gel column,octadecylsilyl(ODS)column,and high performance liquid chromatography.Then,the structures of the isolated compounds were identified based on physicochemical properties and nuclear magnetic resonance spectra.Results:Thirteen compounds were isolated and identified as cis-syringin(1),roseosideⅡ(2),2-phenylethyl-β-D-glucopyranoside(3),vomifoliol(4),4-C-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl]-1,3,6-trihydroxy-7-methoxy-xanthone(5),grasshopper ketone(6),3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-propan-1-one(7),polygalatenoside A(8),robinlin(9),3′,5′-dimethoxy-biphenyl-4-ol(10),phomolide A(11),garcimangosone D(12),and spicellamide A(13),respectively.Conclusion:Compounds 2,4,6,7,and 9-13 were isolated from Polygalaceae for the first time.