纤维状蛋白质基智能材料研究进展

Research progress of fibrous protein-based smart materials

纤维状蛋白质作为构成生命体的物质基础,不仅具有生物相容性和可降解性好的特点,而且对外界环境的刺激具有响应性及可调控性好等功能.因此,纤维状蛋白质在智能材料的研究及应用方面具有很大的发展潜力.目前,有关纤维状蛋白质的研究与应用,已经引起了人们的广泛关注.本文主要综述了近些年丝素蛋白、角蛋白、胶原和弹性蛋白等常见纤维状蛋白质在智能材料方面的应用现状及进展情况;介绍及分析了利用纤维状蛋白质设计具有pH值响应性、温敏性、光敏性、湿敏性及构象变化响应的智能材料的方法和存在问题;讨论了其在智能水凝胶材料、智能生物传感器材料、智能3D打印油墨及智能柔性可穿戴材料等方面的应用优势.这对今后设计具有特异结构、生物相容性、多功能性、刺激响应性等新型智能蛋白质材料具有重要的指导意义.

Fibrous proteins,as the main constituent base of life,not only have the natural advantages of biocompatibility and degradability,but also exhibit the function of good response and regulation to external environment stimulation.Therefore,fibrous protein has great development potential in the research and application of intelligent materials.At present,the research and application of fibrous protein have attracted the attention of researchers.This paper mainly reviews the research status and progress of common fibrous proteins such as silk fibroin,keratin,collagen and elastin in smart materials in recent years.Besides,the paper introduces and analyzes the design method and existing problems of smart materials with pH responsiveness,temperature sensitivity,photosensitivity,moisture sensitivity and conformational change response prepared from fibrillar proteins.Their application advantages in intelligent hydrogel materials,intelligent biosensor materials,intelligent 3D printing inks and intelligent flexible wearable materials are also discussed.This paper will provide guidance for the future design of new intelligent protein materials with specific structure,biocompatibility,versatility and stimulus response etc.