摘要
随着全球老龄化日益严重,衰老相关问题成了健康领域的一个研究热点。近年来,动物衰老模型得到广泛开发与应用,在衰老机制研究中具有重要意义。其中,线虫和果蝇等寿命较短的动物在衰老研究中具有天然优势;各类大鼠、小鼠衰老模型被用于多种衰老研究;同时,非洲青鳉鱼等新型动物衰老模型也相继得以开发应用。本文回顾了目前在衰老研究中使用的主要动物模型,并对各模型的建立方法、模型成功与否的评价指标、优缺点进行分析,以期为相关研究提供参考。
With the increasing severity of global aging,aging-related issues have become the hotspot in the field of health.In recent years,animal aging models have been widely developed and applied,which is of great significance in the study of aging mechanism.Animals with short life span,such as Caenorhabditis Elegans and Drosophila Melanogaster,have natural advantages in the study of aging.Various rat and mouse aging models have been used in aging studies.In recent years,new animal aging models have been developed,such as the African turquoise killifish.The authors reviewed main animal models used in the study of aging,and analyzed the establishment methods,evaluation indexes,advantages and disadvantages of each model in order to provide reference for related research.
作者
尹丹阳
胡怡
史仍飞
YIN Danyang;HU Yi;SHI Rengfei(School of Exercise and Health,Shanghai University of Sport,Shanghai 200438,China)
出处
《实验动物与比较医学》
CAS
2023年第2期156-162,共7页
Laboratory Animal and Comparative Medicine
基金
国家自然基金面上项目“低雌激素条件下肌源性17β-estradiol介导的运动预防肌少症的机制研究”(32171136)
上海自然科学基金资助项目“运动对骨骼肌Aromatase/17β-estradiol通路的影响及功能研究”(19ZR1452900)
国家重点研发项目子课题“肌少症被动运动干预研究及验证”(2020YFC2005604)。
关键词
衰老
动物模型
评价
Aging
Animal model
Evaluation
