应激性心肌病动物模型的研究进展

Research Progress of Animal Models of Stress Cardiomyopathy

应激性心肌病(stress cardiomyopathy,SC)是一种由强烈精神刺激或躯体应激所致的急性心肌病。目前,在SC的急性或慢性阶段,能够有效降低死亡率、改善预后或预防复发的干预措施极少。因此,通过建立一种可靠、有效的SC动物模型来研究SC的发病机制及其防治方法,尤为重要。本文梳理了国内外现有SC模型的制备方法和评价指标,并展开综述,即论述了儿茶酚胺类激素注射法、束缚法、束缚联合电击法、束缚联合脱水法、迷走神经电刺激等造模方法的操作细节,以及利用旷场实验、心超、心电图、ELISA等方法对相关指标进行评价,以期为研究SC时的模型选择和建立提供有益参考。

Stress cardiomyopathy(SC)is an acute cardiomyopathy caused by intense mental stimulation or physical stress.Currently,few interventions are effective in reducing mortality,improving prognosis,or preventing recurrence in acute or chronic stages of SC.Therefore,it is particularly important to establish a reliable and effective SC animal model to study the pathogenesis and prevention of SC.In this paper,the preparation methods and evaluation indexes of SC models at home and abroad were reviewed,including the operation details of catecholamine hormone injection method,binding method,binding combined with electroshock method,binding combined with dehydration method,vagus nerve electrical stimulation and other modeling methods,as well as evaluation indexes such as open field test,cardiac ultrasound,electrocardiogram and ELISA,striving to provide useful reference for model selection and establishment of SC research.