NLR、PLR与高危型人乳头瘤病毒感染相关的宫颈病变的研究进展

慢性炎症与肿瘤的发生发展息息相关。研究发现中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)可能作为炎症标记物,预测各种疾病的进展或预后。NLR、PLR已被证明是子宫颈癌治疗结果及预后的重要预测因子。然而,这两个参数在高危型人乳头瘤病毒感染过程中的临床意义尚不清楚。本综述总结了当前关于NLR、PLR在子宫颈癌中的临床价值,并探讨在高危型人乳头瘤病毒感染的宫颈病变患者中NLR、PLR与疾病严重程度之间的关系。

Chronic inflammation is closely linked to the development of cancer.Studies have found that neutrophil⁃to⁃lymphocyte ratio(NLR)and platelet⁃to⁃lymphocyte ratio(PLR)may be used as inflammatory markers to predict the progression or prognosis of various diseases.NLR and PLR have been shown to be significant predictors of treatment outcome and prognosis in cervical cancer.However,the clinical significance of these two parameters in the course of high⁃risk HPV infection is unclear.This review summarizes current information on the clinical value of NLR and PLR in cervical cancer,and examines the relationship between NLR and PLR and disease severity in patients with high⁃risk human papilloma virus infection in cervical lesions.