永久性心房颤动合并阻塞性睡眠呼吸暂停低通气综合征患者血清低密度脂蛋白的水平变化及临床意义

Changes and clinical significance of serum low density lipoprotein in patients with permanent atrial fibrillation complicated with obstructive sleep apnea hypopnea syndrome

目的探讨永久性心房颤动合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清低密度脂蛋白的水平变化及临床意义。方法选择2019年5月至2021年4月上海市奉贤区中心医院接诊的100例永久性心房颤动合并OSAHS患者作为观察组进行研究,并选择我院接诊的永久性心房颤动患者100例作为对照组。比较两组患者的血清低密度脂蛋白(LDL)、呼吸暂停低通气指数(AHI)、Epworth嗜睡量表(ESS)评分、左室舒张末期内径(LVEDD)、左房舒张末期前后径(LAED)、左室射血分数(LVEF)的水平表达,并采用Pearson相关性分析法分析血清LDL、AHI、ESS评分与LVEDD、LAED、LVEF水平的相关性。结果观察组患者的血清LDL、AHI、ESS评分分别为(14.66±1.31)μg/mL、(22.83±4.25)次/h、(10.16±2.38)分,均明显高于对照的(10.25±1.20)μg/mL、(3.32±0.48)次/h、(6.24±0.50)分,差异有统计学意义(P<0.05);观察组患者的LVEDD、LAED水平分别为(67.48±7.80)mm、(60.20±6.19)mm,均明显高于对照组的(60.69±5.97)mm、(52.09±4.30)mm,LVEF水平(34.23±3.58)%明显低于对照组的(41.00±6.52)%,差异有统计学意义(P<0.05);经Pearson相关分析结果显示,血清LDL、AHI、ESS评分与LVEDD、LAED水平均呈正相关(r=0.740、0.500、0.493、0.639、0.463、0.788,P<0.05),与LVEF水平均呈负相关(r=-0.428、-0.510、-0.302,P<0.05)。结论永久性心房颤动合并OSAHS患者血清LDL水平、AHI、ESS评分升高与心功能障碍密切相关,对其检测有助于临床治疗和疾病评估。

Objective To study changes and clinical significance of serum low density lipoprotein in patients with permanent atrial fibrillation complicated with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Totally 100 patients with permanent atrial fibrillation and OSAHS admitted to our hospital from May 2019 to April 2021 were selected as the observation group for study,and 100 patients with permanent atrial fibrillation admitted to our hospital were selected as the control group.The serum low density lipoprotein(LDL),apnea-hypopnea index(AHI),Epworth sleepiness scale(ESS)score,left ventricular end diastolic diameter(LVEDD),left atrium end diastolic anteroposterior diameter(LAED)and left ventricular ejection fraction(LVEF)level expression were compared between the two groups of patients,and Pearson correlation analysis method was used to analyze the correlation between serum LDL,AHI,ESS scores and LVEDD,LAED,LVEF levels.Results The serum LDL,AHI,and ESS scores of the observation group were(14.66±1.31)μg/mL,(22.83±4.25)times/h,and(10.16±2.38)scores,which were significantly higher than those of the control group(10.25±1.20)μg/mL,(3.32±0.48)times/h,(6.24±0.50)scores,and the differences were statistically significant(P<0.05);the LVEDD and LAED levels in observation group were(67.48±7.80)mm and(60.20±6.19)mm,which were significantly higher than those of control group(60.69±5.97)mm and(52.09±4.30)mm,LVEF level(34.23±3.58)%was significantly lower than that of control group(41.00±6.52)%,and the difference was statistically significant(P<0.05);the results of Pearson correlation analysis showed that serum LDL,AHI,ESS scores were positively correlated with LVEDD and LAED levels(r=0.740,0.500,0.493,0.639,0.463,0.788,P<0.05),and negatively correlated with LVEF levels(r=-0.428,-0.510,-0.302,P<0.05).Conclusion The elevated serum LDL levels,AHI and ESS scores of patients with permanent atrial fibrillation and OSAHS are closely related to cardiac dysfunction,and its detection is helpful for clinical treatment and disease evaluation.