英夫利昔单抗联合硫唑嘌呤治疗儿童克罗恩病的药学监护

Pharmaceutical Care of Infliximab Combined with Azathioprine in the Treatment of Crohn’s Disease in a Child

目的:探讨临床药师在儿童克罗恩病个体化治疗中的药学监护作用。方法:1例克罗恩病患儿拟应用英夫利昔单抗联合硫唑嘌呤治疗;临床药师以免疫调节治疗方案的选择、给药剂量的调整及药品不良反应监测等为切入点,结合基因检测,根据患儿实际情况,配合临床制定个体化给药方案及监护计划。结果:临床药师协助临床医师制定了合理的治疗方案,使患儿症状得到控制,降低了药物发生不良反应的风险。结论:在临床治疗过程中,临床药师发挥药学专业优势,优化给药方案,可减少药物不良反应,促进临床合理用药。

Objective:To explore the role of clinical pharmacists in the individualized treatment and pharmaceutical care of Crohn’s disease in a child.Methods:With the selection of immunomodulatory treatment plan,dosage adjustment and adverse drug reaction monitoring as the entry point,combined with genetic testing,clinical pharmacists formulated individualized dosing plans and monitoring plans according to the actual conditions of the patients and cooperated with the clinic.Results:The clinical pharmacist assisted the clinic in formulating a reasonable treatment plan based on the actual situation of the patient,so that the patient’s symptoms were controlled and the occurrence of adverse drug reactions was reduced.Conclusion:In the process of clinical treatment,clinical pharmacists have exerted their professional advantages in pharmacy,optimized clinical dosing regimens,reduced adverse drug reactions,and promoted rational clinical use of drugs.