镁配合物催化丙交酯开环聚合研究进展

Research Progress on Ring-Opening Polymerization of Lactide Catalyzed by Magnesium Complexes

金属配合物催化丙交酯开环聚合是目前研究较多的合成聚丙交酯的方法,其中镁配合物由于无毒、良好的生物相容性、高催化活性而备受关注。文章综述了镁配合物催化丙交酯开环聚合研究进展,重点介绍了配合物及结构设计,讨论催化剂结构对聚合反应活性剂、立体选择性的影响,并对相应的催化体系优缺点进行分析,对未来研究方向及重点提出建议及展望。结果表明:异配位镁配合物通常具有较高的催化活性,能够对聚合物进行可控聚合。但异配位镁配合物活性稳定性较低,对聚合单体的纯度要求较高。均配位镁配合物的化学稳定性较异配位镁配合物稳定,但除个别配合物具有高催化活性外,其他配合物催化活性较低,立体选择性较差。

Ring-opening polymerization of lactide catalyzed by metal complexes is a widely studied method for the synthesis of polylactide.Among them,magnesium complexes have attracted much attention due to their non-toxicity,good biocompatibility and high catalytic activity.The research progress of ring-opening polymerization of lactide catalyzed by magnesium complexes was reviewed.The structure design of complexes was mainly introduced.The influence of catalyst structure on polymerization activator and stereoselectivity was discussed.The advantages and disadvantages of the corresponding catalytic system were analyzed.Suggestions and prospects for future research directions and key points were put forward.The results show that heterocoordinated magnesium complexes usually have high catalytic activity and can control the polymerization of polymers.However,the activity stability of the hetero-coordinate magnesium complex is low,and the purity of the polymerization monomer is required.The chemical stability of homo-coordinated magnesium complexes is more stable than that of hetero-coordinated magnesium complexes.However,except for some complexes with high catalytic activity,other complexes have low catalytic activity and poor stereoselectivity.