2017—2021年北京佑安医院未接受抗病毒治疗中老年HIV感染者焦虑抑郁现状分析

Prevalence of anxiety and depression among middle-aged and elderly HIV-infected patients without receiving antiretroviral therapy at Beijing You’an hospital from 2017 to 2021

目的了解北京市未接受抗病毒治疗中老年HIV感染者的焦虑、抑郁发病现状,探索影响发生焦虑和抑郁的相关因素。方法采用横断面调查方法纳入2017—2021年首都医科大学北京佑安医院未接受艾滋病抗病毒治疗的中老年HIV感染者245例,使用《医院用焦虑抑郁自评量表》了解研究对象的焦虑、抑郁情况。采用多因素Logistic回归分析抗病毒治疗前焦虑和抑郁的相关影响因素,以P<0.05为差异有统计学意义。结果中老年HIV感染者中,男性占91.0%(223/245),76.7%的婚姻状态为在婚,异性性传播(79.6%);发生焦虑和抑郁的(37.1%)。多因素分析结果显示,婚姻状况为离异或丧偶的研究对象相对在婚的是发生焦虑(OR=0.421,95%CI:0.208~0.852)和抑郁(OR=0.357,95%CI:0.198~0.644)的保护因素;初始CD4^(+)T淋巴细胞计数>200个/μl相对于≤200个/μl是发生焦虑的危险因素(OR=3.364,95%CI:1.806~6.266)。结论北京市未接受抗病毒治疗中老年HIV/AIDS感染者焦虑、抑郁发生率较高;医疗人员应加强入组治疗前的健康教育、心理评估和心理辅导工作,给予必要的支持和关怀。

Objective To investigate the prevalence of anxiety and depression among middle-aged and elderly HIV-infected people without antiretroviral therapy in Beijing,and to explore the related factors affecting the prevalence of anxiety and depression.Methods The method of a cross-sectional survey was used to collect 245 cases of the anxiety and depression of HIV infected patients who were going to receive antiretroviral therapy at Beijing You'an Hospital of Capital Medical University from 2017 to 2021,Hospital Anxiety and Depression Assessment Scale was used to understand the anxiety and depression of the subjects. Multivariate logistic regression analysis wasused to analyze the related influencing factors of anxiety and depression before initiatingantiretroviral therapy. The differences P<0.05 was considered to be statistically significent. Results Among the middle-aged and elderly HIV-infected patients,91.0%(223/245) were male,76.7% weremarried, and 79.6% were heterosexual transmission. The prevalence of anxiety and depressionaccounted for 37.1%. The results of multivariate logistic regression analysis showed that the maritalstatus of divorced or widowed subjects was a protective factor for anxiety (OR=0.421, 95%CI:0.208-0.852) and depression (OR=0.357,95%CI:0.198-0.644) compared with those of marriedsubjects. Initial CD4^(+)T lymphocyte count >200/μl was a risk factor for anxiety compared with ≤200/μl (OR=3.364,95%CI:1.806-6.266) . Conclusions The prevalence of anxiety and depressionin middle- aged and elderly HIV/AIDS patients without antiretroviral therapy in Beijing is high.Health education, psychological evaluation and counseling,and necessary supports and care shouldbe provided before treatment by medical staff.