胆汁酸与非酒精性脂肪性肝病的关系

Association between bile acids and nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)患病率的迅速增加亟需新的治疗方法来预防疾病进展为肝纤维化、肝硬化及肝癌。尽管已经为阐明NAFLD疾病进展的病理机制做出了不懈努力,但目前尚无有效的治疗方法。胆汁酸(BA)通过激活核受体和G蛋白偶联受体调控全身代谢,已被确定为参与脂质、葡萄糖和能量代谢的重要信号分子。BA稳态的失调与NAFLD疾病的严重程度有关。本文总结了BA代谢中的重要配体和其在NAFLD进展中的作用,以期为靶向BA信使治疗NAFLD提供依据。

With the rapid increase in the prevalence rate of nonalcoholic fatty liver disease(NAFLD),new treatment methods are needed to prevent disease progression to liver fibrosis,liver cirrhosis,and liver cancer.Although great efforts have been made to clarify the pathological mechanisms of NAFLD disease progression,there are still no effective treatment methods at present.Bile acids(BAs)regulate systemic metabolism by activating nuclear receptors and G protein-coupled receptors and have been identified as important signaling molecules involved in lipid,glucose,and energy metabolism.Dysregulation of BA homeostasis is associated with the severity of NAFLD.This article summarizes the important ligands in BA metabolism and their role in the progression of NAFLD,in order to provide a basis for the treatment of NAFLD by targeting BA messengers.