骨形态发生蛋白4在非酒精性脂肪性肝病发病机制中的作用

Role of bone morphogenetic protein-4 in the pathogenesis of nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)目前已成为全球最常见的慢性肝病之一,严重危害人类健康。近年来研究发现骨形态发生蛋白4(BMP4)与NAFLD之间可能存在一定相关性。本综述旨在依据国内外关于BMP4与NAFLD相关研究的最新进展,探究BMP4作用于NAFLD的潜在机制,以期为NAFLD的预防及治疗提供新的思路。

Nonalcoholic fatty liver disease(NAFLD)has become one of the most common chronic liver diseases in the world,and it seriously harms human health.Recent studies have found that bone morphogenetic protein 4(BMP4)might be associated with NAFLD.This article reviews the latest advances in the research on the association between BMP4 and NAFLD in China and globally and explores the potential mechanism of action of BMP4 on NAFLD,in order to provide new ideas for the prevention and treatment of NAFLD.