摘要
Cancer is one of the most harmful diseases in the world, which causes huge numbers of deaths every year. Manydrugs have been developed to treat tumors. However, drug resistance usually develops after a period of time,which greatly weakens the therapeutic effect. Tumor drug resistance is characterized by blocking the action ofanticancer drugs, resisting apoptosis and DNA repair, and evading immune recognition. To tackle tumor drugresistance, many engineered drug delivery systems (DDS) have been developed. Metal-organic frameworks(MOFs) are one kind of emerging and promising nanocarriers for DDS with high surface area and abundant activesites that make the functionalization simpler and more efficient. These features enable MOFs to achieveadvantages easily towards other materials. In this review, we highlight the main mechanisms of tumor drugresistance and the characteristics of MOFs. The applications and opportunities of MOF-based DDS to overcometumor drug resistance are also discussed, shedding light on the future development of MOFs to address tumor drugresistance.
