铋基纳米药物系统的抗肿瘤诊疗及生物安全性研究进展

Advance on anti-tumor theranostics and biosafety of bismuth-based nanomedicine

纳米生物医学是生物医药领域中最具有应用前景的方向之一,无机纳米材料由于其优良的物理、化学特性、稳定的化学性质以及高生物相容性,在众多的纳米材料中脱颖而出。作为一种低成本的无机纳米材料,铋基纳米材料由于具有带隙可调、低毒性、易于功能化、较大X射线衰减系数、较高光热转换效率和长循环半衰期等优势,在癌症诊断和治疗方面具有种种潜在的用途和广阔的应用前景。本文综述了铋基纳米材料在肿瘤诊断、治疗和生物安全性方面的最新研究进展,为新一代铋基纳米药物系统的设计和开发提供理论依据和开发思路。

Nanomedicine is one of the most promising fields in biomedicine.Inorganic nanomaterials stand out among many nanomaterials due to their excellent physicochemical properties,stable chemical properties and high biocompatibility.As an inorganic nanomaterial,bismuth-based nanomaterials have the advantages of adjustable band gap,low toxicity,easy functionalization,large X-ray attenuation coefficient,high photothermal conversion efficiency and long cycle half-life,so they have good promising application in cancer diagnosis and treatment.This review summarizes the recent research progress of bismuth-based nanomaterials in tumor diagnosis,treatment and biosafety,which provides a theoretical basis for the design and exploitation of a new generation of bismuth-based nanomedicine systems.