NOD2介导的信号通路及其与自身炎症性疾病关系以及抑制剂研究进展

Research progress of NOD2-mediated signaling pathways and relationship with autoinflammatory diseases and its inhibitors

核苷酸结合寡聚化结构域蛋白2(nucleotide-binding oligomerization domain containing 2,NOD2)是一类胞浆内模式识别受体,其被激活后通过一系列信号级联转导,诱导炎症因子释放,从而在固有免疫应答中发挥重要作用。NOD2信号通路异常涉及多种疾病的发生和发展,尤其是其基因的遗传多态性与自身炎症性疾病(autoinflammatory diseases,AIDs)密切相关。因此,靶向NOD2通路的抑制剂在炎症免疫性疾病治疗中具有巨大潜力。基于此,本文对NOD2受体介导的信号转导通路及其调节机制,NOD2与AIDs的关系以及NOD2通路抑制剂研究的最新进展进行综述。

Nucleotide-binding oligomerization domain containing protein 2(NOD2)is a member of intracellular pattern recognition receptor.After being activated,it will induce the release of inflammatory factors through a series of signal cascade transduction,thus playing an important role in the innate immune response.The abnormal NOD2 signaling pathway is involved in the occurrence and development of many diseases,especially the single nucleotide polymorphisms(SNPs)of the NOD2 gene have been identified to be closely associated with autoinflammatory diseases(AIDs).Therefore,inhibitors targeting NOD2 pathway have great potential in the treatment of inflammatory immune diseases.This review presents the recent progress of NOD2 receptor-mediated signal transduction pathways and its regulation mechanisms,the relationship between NOD2 and AIDs,and the inhibitors of NOD2 pathway.