左氧氟沙星联合替硝唑对盆腔炎患者免疫功能及炎症反应的影响

Effects of levofloxacin combined with Tinidazole on immune function andinflammatory response in patients with pelvic inflammatory disease

目的:探讨对盆腔炎患者替硝唑治疗同时予左氧氟沙星干预对免疫功能及炎症反应的影响。方法:选择本院2021年1月至2021年12月收治的90例盆腔炎患者,随机分为替硝唑单药治疗对照组(n=45)与联用左氧氟沙星治疗观察组(n=45),均在用药2周后比较两组临床疗效,检测治疗前后T细胞亚群水平评估免疫功能,另检测C反应蛋白(CRP)、白介素(IL)-8及肿瘤坏死因子(TNF)-α水平评估炎症反应,并比较不良反应率评估用药安全性。结果:观察组联用左氧氟沙星干预后总有效率较对照组高(95.56%vs 80.00%,P<0.05);治疗后观察组CD3+(69.46±5.52)%、CD4+(39.12±3.84)%、CD4+/CD8+(1.84±0.25),均高于对照组(P<0.05);治疗后观察组CRP(5.84±1.87)mg/L、IL-8(144.07±41.52)pg/mL、TNF-α(19.57±4.15)pg/mL,均小于对照组(P<0.05)。两组不良反应率无显著差异(8.89%vs 4.44%,P>0.05)。结论:对盆腔炎患者予左氧氟沙星联合替硝唑治疗疗效确切,能改善机体免疫功能与炎症反应。

Objective:To investigate the effects of tinidazole therapy combined with levofloxacin intervention on immune function and inflammatory response in patients with pelvic inflammatory disease.Methods:A total of 90 patients with pelvic inflammatory disease patients admitted from January to December in 2020 were randomly divided into tinidazole treatment group(n=45)treated with tinidazole monotherapy and the observation group treated with levofloxacin(n=45).After 2 weeks of treatment,the effect of pelvic inflammatory disease in two groups was evaluated,and the level of T cell subsets before and after treatment was detected to evaluate the immune function.The levels of C-reactive protein(CRP),interleukin-8(IL-8)and tumor necrosis factor(TNF-α)were also measured to evaluate the inflammatory response,and the adverse reaction rate was compared to evaluate the drug safety.Results:The total effective rate of the observation group combined with levofloxacin was higher than control group(95.56%vs 80.00%,P<0.05).After treatment,CD3+(69.46±5.52)%,CD4+(39.12±3.84)%and CD4+/CD8+(1.84±0.25)in the combined levofloxacin group had better levels(P<0.05).After treatment,the CRP(5.84±1.87)mg/L,IL-8(144.07±41.52)pg/mL and TNF-α(19.57±4.15)pg/mL in low levels were observed in the combined levofloxacin group(P<0.05).The two groups are equally secure(8.89%vs 4.44%,P>0.05).Conclusion:Levofloxacin combined with tinidazole is effective in the treatment of pelvic inflammatory disease,which can improve the immune function and inflammatory response of the body.