小反刍兽疫病毒与宿主细胞相互作用的研究进展

Research progress of interaction between peste des petits ruminants virus and host cells

小反刍兽疫(peste des petits ruminants,PPR)是由小反刍兽疫病毒(peste des petits ruminants virus,PPRV)感染引起的一种高感染性、高致死率疾病,给国内外养羊业带来巨大经济损失。认识和了解PPRV与宿主的相互作用是了解致病机制的基础和疫病防控的前提。本文对PPRV侵染宿主机体后激活宿主天然免疫应答,病毒蛋白产物介导PPRV实现免疫逃逸,以及诱导细胞凋亡、自噬和炎症小体抵抗病毒等方面的相关研究作一综述,为深入探讨PPRV的免疫逃避作用以及PPRV与宿主相互作用涉及的关键节点提供参考,从而为有效防控PPR的传播提供理论依据。

Peste des petits ruminants(PPR)is a highly contagious disease with high mortality which is caused by peste des petits ruminants virus(PPRV)infection and leads to enormous economic losses for sheep husbandry both at home and abroad.The knowledge of interactions between PPRV and host cells is the basis of understanding of the pathogenesis and the prerequisite of disease prevention and control.This paper reviews the studies on the activation of host innate immune response by PPRV infection,the immune evasion of PPRV mediated by viral protein products,and the induction of apoptosis,autophagy and inflammasome resistance to virus,which provides a reference for further discussion on the immune evasion of PPRV and the key nodes involved in the interaction between PPRV and the host,thus providing theoretical guidance for effective prevention and control of PPR transmission.