可降解聚肟氨酯材料的设计研制及其3D打印

Design,Development and 3D Printing of Biodegradable Poly(Oxime Urethane)Material

针对生物医学应用,研制了一种新型的具有良好降解性和可3D打印的聚氨酯材料——聚肟氨酯。通过聚己内酯二醇、丁二酮肟和异佛尔酮二异氰酸酯的两步缩聚反应制备得到了可降解的聚己内酯基聚肟氨酯材料(PCL-PU)。利用傅里叶变换红外光谱、核磁共振氢谱、凝胶渗透色谱分析、热重分析、差示扫描量热法、流变学测试、体外酶促降解实验、单轴拉伸试验和压缩试验等分析测试方法对PCL-PU的分子结构和性能进行了表征。研究结果表明,成功合成了聚己内酯基聚肟氨酯材料,该材料具有良好的热稳定性、可降解性和力学性能,体外降解7 d后该材料的降解率可达(44.3±12.9)%。同时,PCL-PU具有良好的加工性能,在99℃时可方便快捷地3D打印。该材料有望应用于组织工程支架等生物医学领域。

A novel polyurethane material—poly(oxime urethane),which with good degradability and 3D printing ability,was developed for biomedical applications.The biodegradable polycaprolactone based poly(oxime urethane)(PCL-PU)was synthesized by two-step polycondensation of polycaprolactone diol,isophorone diisocyanate and dimethylglyoxime.The structure and properties of PCL-PU were characterized by Fourier transform infrared spectroscopy(FTIR),nuclear magnetic resonance(^(1)H-NMR),gel permeation chromatography(GPC),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),rheological measurement,enzymatic degradation test,uniaxial tensile test and compression test.The results showed that PCL-PU was successfully synthesized.PCL-PU possessed good thermal stability,degradability and mechanical properties.After degradation for 7 d,the degradation rate of PCL-PU reached(44.3±12.9)%.At the same time,PCL-PU possessed good processibility and could be readily 3D printed at 99℃.This material was expected to be applied in the field of biomedicine such as tissue engineering scaffolds.