纳米炭在结直肠癌手术中的应用进展

The Application and Progress of Carbon Nanoparticles in Colorectal Cancer Surgery

结直肠癌是目前发病率和死亡率最高的恶性肿瘤之一,术后检出足够多的淋巴结对获得准确的结直肠癌分期至关重要。纳米炭是一种新型淋巴示踪剂,具有淋巴系统趋向性、安全性、长效性等优势,能够准确定位肿瘤、示踪区域淋巴结,协助确定淋巴清扫范围,降低手术难度,保留更多肠管,提高术后淋巴结检出数目,减少手术时间及住院时间,因此在结直肠癌手术中得到了广泛应用。本文介绍了纳米炭示踪淋巴结的原理、优势及其在结直肠手术中的应用效果,并进一步探讨其未来的研究方向。

Colorectal cancer is one of the most common cancer types with the highest morbidity and mortality.It is necessary to harvest sufficient lymph nodes to perform an accurate postoperative pathologic assessment.Carbon nanoparticles have been widely used as a new kind of tracer in colorectal cancer due to its lymphotropic property,safety and long effectiveness.Carbon nanoparticles were reported to be able to help locate the primary tumor,trace regional lymph nodes,determine the extent of lymph node excision,reduce surgical difficulty,preserve more intestines,increase the number of postoperative lymph node detection,and reduce the operation time and hospital stay.In this article,the mechanism of carbon nanoparticles will be introduced.The effect in colorectal surgery and further research direction will be reviewed.