原发性失眠大脑默认网络功能损害的特点及其机制

Characteristics and Mechanism of Brain Default Mode Network Dysfunction in Primary Insomnia

原发性失眠是常见的睡眠障碍之一,属于原因不明的失眠类型,常常伴有多种日间功能损害和睡眠-觉醒紊乱。神经影像学及神经电生理学研究提示,原发性失眠患者可能存在默认网络功能损害,并与患者的日间功能障碍和睡眠-觉醒紊乱密切相关。本文对原发性失眠的默认网络功能损害特点进行总结,并介绍在神经结构影像学、功能影像学和神经电生理学方面的相关研究及默认网络功能损害引发原发性失眠日间功能损伤和睡眠-觉醒紊乱的作用和机制。

Primary insomnia is one of the common sleep disorders.It is a type of insomnia with unknown causes,which is often accompanied by a variety of daytime dysfunction and sleep-wake disorders.Neuroimaging and neuroelectrophysiology studies suggest that there may be default mode network dysfunction in patients with primary insomnia,which is closely related to daytime dysfunction and sleep-wake disorder.This article summarizes the characteristics of default mode network dysfunction of primary insomnia and introduces related research in neural structural imaging,functional imaging and neuroelectrophysiology,as well as the role and the mechanism of default mode network impairment leading to daytime dysfunction and sleep-wake disorder of primary insomnia.