摘要
目的探讨血α1微球蛋白(α1-MG)、β2微球蛋白(β2-MG)、胱抑素C(Cys C)及尿微量蛋白(mALb)对高血压早期肾损害的诊断价值。方法选择2018年1月至2020年3月本院收治的60例高血压患者为高血压组,60例高血压早期肾病患者为高血压肾病组,60例健康体检者为对照组。比较3组血α1-MG、β2-MG、Cys C和尿mALb水平,分析血α1-MG、β2-MG、Cys C和尿mALb单一和联合检测高血压早期肾病的价值。结果高血压肾病组血α1-MG[(41.78±12.26)mg/L]、β2-MG[(4.60±1.27)mg/L]、Cys C[(1.35±0.32)mg/L]及尿mALb[(80.74±10.49)mg/L]含量高于高血压组、对照组,高血压组血上述指标含量高于对照组,差异均有统计学意义(F分别为24.687、22.186、17.964、36.417,均P<0.05)。血α1-MG、β2-MG、Cys C及尿mALb联合诊断高血压早期肾病的敏感度(95.00%)高于Cys C(83.33%)、β2-MG(68.33%)、α1-MG(61.67%),特异度(96.67%)高于α1-MG(86.67%)、β2-MG(80.00%)、mALb(76.67%),准确度(95.83%)高于血α1-MG(74.17%)、β2-MG(74.17%)、Cys C(87.50%)及尿mALb(80.83%)单一诊断,差异均有统计学意义(均P<0.05)。结论血α1-MG、β2-MG、Cys C和尿mALb均是诊断高血压早期肾病的有效指标,上述指标联合诊断能够提高疾病检出率。
Objective This study was designed to explore the diagnostic value ofα1-MG,β2-MG,Cys C and mALb in early renal damage of hypertension.Methods From January 2018 to March 2020,60 patients with hypertension were se-lected as hypertension group,60 patients with early hypertensive nephropathy as hypertensive nephropathy group,and 60 healthy people as control group.We compared the levels ofα1-MG,β2-MG,Cys C and urine mALb in three groups,and analyzed the value of single and combined detection ofα1-MG,β2-MG,Cys C and urine mALb in early hypertensive ne-phropathy.Results Bloodα1-MG[(41.78±12.26)mg/L],β2-MG[(4.60±1.27)mg/L],Cys C[(1.35±0.32)mg/L]and urine mALb[(80.74±10.49)mg/L]in hypertensive nephropathy group were higher than those of the hyper-tension group and the control group,and the contents of the above indexes in the blood of the hypertension group were high-er than those of the control group,with statistical significance(F=24.687,22.186,17.964,36.417,respectively,P<0.05).The sensitivity(95.00%)ofα1-MG,β2-MG,Cys C and urine mALb in the diagnosis of early hypertensive ne-phropathy were higher than Cys C(83.33%),β2-MG(68.33%),andα1-MG(61.67%);Specificity(96.67%)was higher thanα1-MG(86.67%),β2-MG(80.00%),mALb(76.67%),and accuracy(95.83%)was higher than bloodα1-MG(74.17%),β2-MG(74.17%),Cys C(87.50%)and urine mALb(80.83%)diagnosed by single diagnosis,with the difference being statistically significant(all P<0.05).Conclusion Serumα1-MG,β2-MG,Cys C and urine mALb are all effective indicators for the diagnosis of early hypertensive nephropathy.Combined diagnosis can improve the detection rate of diseases and guide the treatment.
作者
王茵
闫国贝
刘芳松
WANG-Yin;YAN Guo-bei;LIU Fang-song(Department of Clinical Laboratory,The Second People's Hospital of Jiaozuo City,Jiaozuo,Henan 454002,China)
出处
《中国卫生工程学》
CAS
2023年第2期195-197,共3页
Chinese Journal of Public Health Engineering
基金
河南省医学科技攻关计划项目(LHGJ20191354)。
关键词
高血压早期肾损害
Α1微球蛋白
胱抑素C
Β2微球蛋白
尿微量蛋白
Renal damage in early stage of hypertension
α1 microglobulin
Cystatin C
β2 microglobulin
Urine microprotein