肠道菌群与男性不育症的相关性

Association of Intestinal Flora with Male Infertility

肠道菌群数量庞大,门类繁多,在人体免疫、代谢及神经调节等方面发挥着不可替代的作用。研究表明肠道菌群与男性不育之间有着密不可分的联系。男性不育症患者肠道菌群与其炎症反应、代谢调节、神经调节和勃起功能障碍发生发展相关,并可能通过内毒素血症、能量代谢、短链脂肪酸、胰岛素抵抗等影响男性生育能力。此外,现已有少量研究应用饮食调节、补充益生菌调控肠道菌群的方法治疗某些疾病,如口服益生菌联合左卡尼汀可降低肥胖男性的精子DNA碎片率等,这为治疗男性不育症提供了新的思路。对肠道菌群与男性不育症相关性进行综述,探讨肠道菌群在男性不育症中的作用,以期为改进临床治疗方案提供借鉴。

The intestinal flora,with a large number and a wide variety of categories,plays an irreplaceable role in human immunity,metabolism,and neuromodulation.Studies have shown an inextricable link between gut microbiota and male infertility.The intestinal flora of male infertility patients is related to the inflammatory response,metabolic regulation,neuromodulation and erectile dysfunction,and may affect male fertility through endotoxemia,energy metabolism,short-chain fatty acids,insulin resistance,etc.In addition,there have been a small number of studies on the clinical practice of dietary modification and supplementation of probiotics to regulate the intestinal flora in the treatment of some diseases.For example,the oral probiotics combined with L-carnitine can reduce the rate of sperm DNA fragmentation in obese men,which provides new ideas for the treatment of male infertility.In this paper,the association between intestinal flora and male infertility was summarized.The discussion of the role of intestinal flora in male infertility will be helpful for improving the clinical treatment options.