线粒体自噬与卵巢功能

Mitophagy and Ovarian Function

线粒体在决定卵母细胞发育能力和卵巢功能方面起重要作用。线粒体自噬是细胞选择性地清除多余或受损的线粒体,与维持细胞内线粒体稳态及细胞存活相关;但自噬被抑制或者被过度激活都可能影响细胞功能和细胞存活。当暴露于不良环境时,卵母细胞线粒体功能受损,诱发过量的线粒体自噬,导致卵母细胞质量下降。排卵后卵母细胞老化,氧化应激致线粒体损伤;应用抗氧化剂可以诱导线粒体自噬以清除受损的线粒体,降低氧化应激,改善卵母细胞的发育潜能。综述卵母细胞线粒体自噬与卵巢功能的关系,以及不良环境刺激和抗氧化剂对卵母细胞线粒体自噬的影响,为抗氧化剂应用于卵巢储备功能下降患者提高卵母细胞质量提供了理论依据。

Mitochondria play a crucial role in determining oocyte development ability and ovarian function.Mitophagy is a process that selectively remove the excess or damaged mitochondria.It is associated with the maintenance of mitochondrial homeostasis and cell survival.However,inhibition or overactivation of mitophagy may affect cell function and cell survival.When exposed to adverse environment,oocyte is impaired in the mitochondrial function,inducing excessive mitophagy.Ultimately,the oocyte quality is declined.The mitochondria of the postovulatory aging oocytes are damaged to a certain extent,the application of antioxidants can induce mitophagy in oocytes to remove the damaged mitochondria and improve oocytes development ability.The relationship between oocytes mitophagy and ovarian function,as well as the effects of adverse environmental stimulation and antioxidants on oocyte mitophagy were reviewed in this paper,to provide a theoretical basis for the application of antioxidants to improve oocyte quality in patients with the decreased ovarian reserve.