晶状体上皮细胞葡萄糖代谢的研究进展

Research progress in glucose metabolism of lens epithelial cell

糖尿病性白内障(DC)是影响糖尿病患者视力的重要原因,其发病机制尚未完全明确。研究表明,葡萄糖代谢紊乱可能是DC形成的重要机制。晶状体上皮细胞(LECs)是晶状体代谢最为活跃的成分,正常的葡萄糖代谢对维持晶状体透明至关重要。在高糖环境下,LECs发生葡萄糖代谢紊乱可能是DC发生发展的重要机制。本文就正常和高糖条件下LECs葡萄糖代谢的特点及其对LECs的影响进行综述,以期为DC的防治提供新的思路。

Diabetic cataract(DC)is an important cause of visual impairment in diabetic patients.However,its patho⁃genesis has not been completely understood.Studies have shown that glucose metabolic disorders may be an essential mechanism for DC.Lens epithelial cells(LECs)are the most active component of lens metabolism.Normal glucose metab⁃olism is essential for maintaining lens transparency.The glucose metabolism of LECs may be disturbed by high glucose,which may play a significant role in the development of DC.This paper summarizes the characteristics of glucose metabo⁃lism in LECs under normal and high glucose conditions and their impact on LECs to provide new ideas for the prevention and treatment of DC.