癫痫发作患者病情严重程度与氧化应激指标、BDNF、IGF-1水平的关系

Relationship of Oxidative Stress,BDNF,and IGF-1 Levels with Severity of Epilepsy

【目的】探讨癫痫发作患者病情程度与氧化应激指标、脑源性神经营养因子(BDNF)和胰岛素样生长因子(IGF-1)水平的关系。【方法】本院收治的198例癫痫发作患者,根据发作严重程度,分为轻度组71例、中度组74例、重度组53例,另选取本院同期体检健康者68例为对照组。比较四组一般资料和血清氧化应激指标[丙二醛(MDA)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、总抗氧化力(T-AOC)]及血清BDNF和IGF-1水平;分析不同病情程度癫痫发作患者各指标水平与病情程度的相关性,并分析血清MDA、CAT、SOD、T-AOC与BDNF、IGF-1水平的相关性。【结果】不同病情程度癫痫发作患者血清CAT、SOD、T-AOC水平显著低于对照组,MDA水平显著高于对照组,且随着病情严重程度增加,CAT、SOD、T-AOC水平呈递减趋势,MDA水平呈递增趋势(均P<0.05)。不同分级癫痫发作患者血清BDNF水平显著低于对照组,IGF-1水平显著高于对照组,且随着病情严重程度增加,BDNF呈递减趋势,IGF-1呈递增趋势(均P<0.05)。Pearson相关分析显示,患者血清CAT、SOD、T-AOC、BDNF水平与病情严重程度均呈负相关(P<0.05),MDA、IGF-1水平则与病情严重程度呈正相关(P<0.05)。BDNF与MDA水平呈负相关(P<0.05),与CAT、SOD、T-AOC水平呈正相关(P<0.05),IGF-1与MDA水平正相关(P<0.05),与CAT、SOD、T-AOC水平负相关(P<0.05)。【结论】癫痫发作患者氧化应激水平及BDNF、IGF-1水平在不同病情程度中存在明显差异,癫痫发作患者病情程度与氧化应激指标、BDNF、IGF-1水平及氧化应激指标水平与BDNF、IGF-1水平存在明显相关性。

【Objective】To explore the relationship of the severity of epileptic seizures with the levels of oxidative stress,brain derived neurotrophic factor(BDNF),and insulin like growth factor(IGF-1).【Methods】According to the severity of seizures,198 patients with epilepsy admitted to our hospital were divided into the mild group of 71 cases,the moderate group of 74 cases,and the severe group of 53 cases.Meanwhile,68 healthy individuals who underwent physical examination at the same time in our hospital were selected as the control group.The general data and serum oxidative stress indicators(MDA,CAT,SOD,T-AOC),as well as serum BDNF and IGF-1 levels were measured and compared among the four groups.We analyzed the correlation between the levels of various indicators and the severity of epilepsy in patients with different grades of epilepsy to show the relationship of severity of epilepsy with serum levels of MDA,CAT,SOD,T-AOC,BDNF,IGF-1.【Results】The levels of serum CAT,SOD and T-AOC in patients with epilepsy of different grades were significantly lower than those in the control group,while the level of MDA was significantly higher than that in the control group.As the severity of the disease increased,the levels of CAT,SOD,and T-AOC showed a downward trend,while the level of MDA showed a increase trend(all P<0.05).Serum BDNF level in patients with epilepsy of different severities was significantly lower than that in the control group,while IGF-1 level was significantly higher than that in the control group.As the severity of the disease increased,BDNF tended to decrease,while IGF-1 tended to increase(all P<0.05).Pearson correlation analysis showed that levels of serum CAT,SOD,T-AOC,and BDNF were negatively correlated with the severity of the disease(P<0.05),while MDA and IGF-1 levels were positively correlated with the severity of the disease(P<0.05).BDNF level was negatively correlated with MDA level,while it was positively correlated with CAT,SOD,and T-AOC levels.The level of IGF-1 was positively correlated with MDA level,and it was negatively correlated with CAT,SOD,and T-AOC levels(P<0.05).【Conclusion】There are significant differences in the levels of oxidative stress,BDNF,IGF-1,and BDNF,IGF-1 in epileptic patients with different severity of illness.The disease severity is significant correlation to the levels of oxidative stress,BDNF and IGF-1 in epileptic patients.