健康体检人群血小板分布宽度与高尿酸血症的相关性分析

Association between platelet distribution width and hyperuricemia in healthy population

目的分析血小板分布宽度(PDW)是否与高尿酸血症(HUA)存在相关性。方法以参加2020年西安交通大学医院健康体检且符合要求的4885名教职工为研究对象,回顾性分析其基本信息、血常规及血清生化指标。所有数据先按性别分组,再分别依据PDW值四分位数将其各自分成四个水平,比较不同PDW水平组血清尿酸(UA)水平及HUA患病率的差异,并分析PDW与年龄、血清生化指标以及血常规其他指标的相关关系;分析HUA患病的相关因素,并进一步分析PDW水平对HUA患病的独立影响。结果男性和女性研究人群PDW四水平组的血清UA水平及HUA患病率呈上升趋势(P<0.05),且PDW水平与血清UA水平呈正相关(P<0.05)。此外,PDW还与年龄、空腹血糖、肝和肾功能指标以及血脂和血常规中的某些指标有关。以上指标中谷丙转氨酶、谷草转氨酶、肌酐、尿素、白细胞计数、红细胞压积以及血脂相关指标可能均是HUA患病相关因素(P<0.05),男性HUA患病相关因素可能还包括血小板计数(P<0.05),女性可能还包括年龄、空腹血糖、血红蛋白量、红细胞分布宽度和PDW(P<0.05)。排除上述混杂因素后,高水平PDW男性HUA患病风险显著升高(P<0.05),而在女性中其差异不具有统计学意义(P>0.05)。结论血清PDW水平与HUA存在一定相关性,且PDW水平可能是男性HUA患病的独立危险因素,但仍需进一步研究。

Objective To analyze the correlation between platelet distribution width(PDW)and hyperuricemia(HUA).Methods For this study we recruited 4885 teaching and administrative staff of Xi’an Jiaotong University who took the physical examination in 2020 and met the requirements.The basic information,blood routine and serum biochemical index results were collected and analyzed retrospectively.Data were sorted by gender,and the serum UA level and the prevalence of HUA in different PDW quartiles were compared after dividing PDW into quartiles.The association of PDW with other indexes including age,serum biochemical indexes and blood routine indexes was analyzed.Then,the factors related to HUA in different genders were analyzed,and the independent influence of PDW on HUA was further analyzed.Results The serum UA level and prevalence of HUA were on the increase among different PDW quartiles both in two genders,and PDW level was positively correlated with serum UA level(P<0.05).In addition,PDW was correlated with age,fasting blood glucose,indicators related to liver and kidney function,and certain indexes of blood lipid and blood routine tests.Among the above indicators,glutamic-pyruvic transaminase,glutamic oxalacetic transaminase,creatinine,urea,white blood cell count,hematocrit,and blood lipid were all significantly associated with HUA in both genders(P<0.05).In addition,HUA significantly associated with platelet count in males(P<0.05),but with age,fasting blood glucose,hemoglobin,red blood cell distribution width,and PDW in females(P<0.05).After excluding the above confounding factors,the risk of HUA in males with high levels of PDW was still significantly increased(P<0.05),but there was no significant difference in females(P>0.05).Conclusion PDW is correlated with HUA,and PDW may be an independent risk factor for HUA in males.However,further study is needed.