生酮饮食激活脂肪酸氧化促进ME区的少突胶质细胞前体细胞增殖

Ketogenic diet promotes the proliferation of oligodendrocyte precursor cells in ME region by activating fatty acid oxidation

下丘脑正中隆起(mdian eminence,ME)是神经元和少突胶质细胞的可能生态位,营养因素可能通过诱导ME区细胞变化而调控下丘脑功能。为了确定生理条件下休眠的下丘脑干细胞是否存在饮食诱导的可塑性,本研究使用正常饲料、高脂饮食和生酮饮食(一种低碳水、高脂肪的饮食)等不同喂养方式,比较了不同饮食条件下小鼠ME区伸展细胞(tanycytes,TCs)和少突胶质细胞前体细胞(oligodendrocyte precursor cells,OPCs)的增殖情况,首次发现生酮饮食可诱导促进ME区OPCs增殖,阻断脂肪酸氧化通路可抑制生酮饮食诱导的OPCs增殖。本研究初步揭示了饮食诱导对ME区OPCs的影响,为进一步研究ME区OPCs的功能提供了启示。

Hypothalamic median eminence(ME)is a potential niche for neurons and oligodendrocytes,and trophic factors may regulate hypothalamic function by inducing cellular changes in the ME region.To determine whether diet-induced plasticity exists in hypothalamic stem cells dormant under physiological conditions,we used a combination of a normal diet,a high-fat diet,and a ketogenic diet(a low-carb,high-fat diet)to compare the proliferation of tanycytes(TCs)and oligodendrocyte precursor cells(OPCs)in the ME area of mice under the different diets.The results showed that the ketogenic diet could induce and promote the proliferation of OPCs in the ME area,and blocking the fatty acid oxidation program could inhibit the proliferation of OPCs induced by a ketogenic diet.This study preliminarily revealed the diet-induced effect on OPCs in the ME region and provided enlightenment for further study on the function of OPCs in the ME region.