发酵纤维素阴离子衍生物的转化与抗菌应用评价

Conversion of anionic derivatives of fermented cellulose and evaluation of their antifungal effect

在水相条件下用阴离子醚化剂(3-氯-2-羟基丙磺酸钠)通过一锅法对经微生物改造的纤维素阴离子化,其中的氢氧化钠溶液既作为反应物、溶剂,又作为催化剂,反应条件温和、取代度适中、转化率较高。采用元素分析、核磁共振、傅里叶红外光谱等表征方法研究了纤维素衍生物的取代度和结构,结果表明,获得的纤维素产物已阴离子化。对纤维素衍生物进行了抑制真菌评估,证明其具其有一定的抑菌特性。纤维素衍生物的生态亲和性决定其可应用于文物保护、农业和防疫等领域。

In this paper it is reported firstly that fermented cellulose was anionized by one pot method with sodium 3-chloro-2-hydroxypropane sulfonate in aqueous phase,and sodium hydroxide solution was used as reactant,solvent,and catalyst.The reaction conditions were mild,the degree of substitution was moderate,and the conversion rate was acceptable.The characterization of cellulose derivative was studied by means of elemental analysis,nuclear magnetic resonance,FTIR and so on.The antifungal biological evaluation of cellulose derivative was carried out,and the results showed that it had certain antifungal properties.The ecological compatibility of cellulose derivatives confirms that they can be applied in archaeology,agriculture and epidemic prevention,etc.